Mutagen Farming - Newgen Guide (2025) - Witcher 3: Wild Hunt

Monster Mutagens

Mutagens is one of the core mechanics that can be used to increase the power of your build. finding more of, and then combining mutagens is one of the ways that the game attempts to help scale our power throughout the playthrough. here are some the best places to find them at different stages of the game. 

Velen

Nekkers

Nekkers can be a dangerous enemy due to their high numbers, and aggressive AI behavior. When fighting them, Igni can be very useful as it can ignite multiple of them. This will them out of the fight long enough for you to kill 1-2 nekkers that were not set ablaze.  

Mutagen	Location	Map
	Monster's nest North of Codger's Quarry.
	Multiple large Nekker nests are found in the empty fields west of Benek.
	Large nest of level 17 Nekkers, and a rock troll to boot. Keep an eye out for witcher gear.

Nekkers are commonly used as unexpected encounters during multiple quests and side quests that take place away from the coast. With a little bit of exploration, finding them should not be challenging.

Endregas

In Velen, endregas usually come un clumps of 4-5 workers and 1-3 warriors. The Warriors have the highest chance to drop mutagens, but are also much more dangerous. Focus the workers first, and leave the warriors for last. Dip in and out of range landing 2 strikes before retreating.  Use Golden Oriole Potion to counteract their poison effect.

Mutagens	Location	Map
	Western Velen, south of the Hangman's Alley. Can respawn so long as you do not open the Guarded Treasure Chest.
	Can be farmed during "The Whispering Hillock" side quest, while dealing with the Crones. Will spawn indefinitely if you choose to kill the Heart of the Tree.
	Endrega nest inside a ruined tower. Keep an eye out for witcher gear.

Alghouls

Alghouls are a dangerous enemy. They are tougher than ghouls, and hit harder too. in addition, they have a shriek move which can stun us in a large radius. Their spikes reflect damage back at Geralt, and stagger him. Use Axii to make them retract their spikes.

Mutagen	Location	Map
	Codgers Quarry sidequest has you help some mercenaries fight off some Alghouls. 4 Alghouls.
	Abandoned fort at the Easternmost cape of Velen is swarming with ghouls and also contains 2 alghouls. Dangerous at early levels.
	The village of Toderas was massacred by Deserters. After dealing with them, in the future, when you return the village will be swarmed with devourers, and 1 alghoul.  Respawning.
	The level 24 Witcher Contract "the Beast of Honorton" will have you fight a total of 6 alghouls, which come in waves of 3, 1 and 2. save the game before each wave to reroll potential drops.

Novigrad

There aren't many places to farm mutagens around Novigrad, and fewer still are better than what can be found in Velen or in Skellige.

Drowned Dead

Fairly easy enemy that behaves exactly the same as normal drowners.

Mutagen	Location	Map
	On the beach, north of Novigrad. (level 30+ enemies) 5 enemies total. Respawning.

Arachas

Armored Arachas are a dangerous lategame enemy, meaning they have a high mutagen drop rate. Refresh Quen shield whenever you take a hit, and be patient.

Mutagen	Location	Map
	In the forest north of Novigrad, above the seaside cavern. High Level enemy. Respawning.

Skellige

There are several fantastic farming spots on the eastern side of Ard Skellig. Skellige is the best place for farming red mutagens, as there are many Drowned dead which are relatively easy to defeat.

Drowned Dead

Mutagen	Location	Map
	Around the Whale Graveyard sign, and further west, along the coast. You must first clear out the bandits occupying the area, for the drowned dead to spawn. ~10 enemies total. Respawning.
	On the coast southwet of Redgill. ~5 enemies total. Respawning.

Endrega Warriors

somewhat dangerous enemies of medium toughness. Can cause knockback, but can be quickly dispatched if you focus on one at a time.

Mutagen	Location	Map
	The entire hillside north-east from the Druid's Camp is swarming with endrega Warriors.  Multiple groups of 2-4. Respawning.

Venomous Arachas 

Very dangerous enemy which can inflict potent poison effects, as well as ensnare you leaving you vulnerable to other enemy attacks. Use Golden Oriole potion to neutralise poison.

Mutagen	Location	Map
	50 meters north-west from the Druids' camp marker. High level enemy. Respawning.